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>BSI Standards >13 ENVIRONMENT. HEALTH PROTECTION. SAFETY>13.280 Radiation protection>BS EN ISO 21243:2025 Radiation protection. Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies. General principles and application to dicentric assay
immediate downloadReleased: 2025-09-30

BS EN ISO 21243:2025

Radiation protection. Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies. General principles and application to dicentric assay

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Standard number:BS EN ISO 21243:2025
Pages:28
Released:2025-09-30
ISBN:978 0 539 36500 9
Status:Standard

BS EN ISO 21243:2025 - A Comprehensive Guide to Radiation Protection in Emergencies

In the ever-evolving landscape of radiological and nuclear safety, the BS EN ISO 21243:2025 standard emerges as a pivotal resource for laboratories tasked with the critical role of performing initial cytogenetic dose assessments during mass casualty events. This standard is meticulously crafted to ensure that laboratories are equipped with the necessary performance criteria to effectively manage and assess radiological or nuclear emergencies.

Key Features of BS EN ISO 21243:2025

  • Standard Number: BS EN ISO 21243:2025
  • Pages: 28
  • Release Date: September 30, 2025
  • ISBN: 978 0 539 36500 9
  • Status: Standard

Understanding the Importance of Cytogenetic Dose Assessment

In the unfortunate event of a radiological or nuclear emergency, rapid and accurate dose assessment is crucial for effective response and management. The BS EN ISO 21243:2025 standard provides a comprehensive framework for laboratories to conduct initial cytogenetic dose assessments, focusing on the application of the dicentric assay. This assay is a well-established method for biological dosimetry, allowing for the precise evaluation of radiation exposure levels in individuals affected by such emergencies.

General Principles and Application

The standard outlines the general principles that laboratories must adhere to when performing cytogenetic dose assessments. It emphasizes the importance of accuracy, reliability, and consistency in the results obtained. By following these principles, laboratories can ensure that their assessments are scientifically sound and can be relied upon for making critical decisions during emergency situations.

The application of the dicentric assay is a central focus of this standard. This assay involves the analysis of chromosomal aberrations, specifically dicentric chromosomes, which are indicative of radiation exposure. The BS EN ISO 21243:2025 standard provides detailed guidance on the implementation of this assay, ensuring that laboratories can perform it with the highest level of precision and accuracy.

Why Choose BS EN ISO 21243:2025?

For laboratories involved in radiation protection and emergency response, the BS EN ISO 21243:2025 standard is an indispensable tool. Here are some reasons why this standard is essential:

  • Comprehensive Guidance: The standard offers detailed instructions and criteria for performing cytogenetic dose assessments, ensuring that laboratories are well-prepared to handle mass casualty events.
  • International Recognition: As an ISO standard, BS EN ISO 21243:2025 is recognized globally, providing a consistent framework for laboratories worldwide.
  • Focus on Accuracy: The standard emphasizes the importance of accuracy and reliability in dose assessments, ensuring that the results are scientifically valid and can be used to inform critical decisions.
  • Up-to-Date Information: Released in 2025, this standard reflects the latest advancements and best practices in the field of radiation protection and cytogenetic dose assessment.

Conclusion

The BS EN ISO 21243:2025 standard is a vital resource for laboratories involved in radiation protection and emergency response. By providing comprehensive guidance on the performance criteria for cytogenetic dose assessments, this standard ensures that laboratories are equipped to handle the challenges of radiological or nuclear emergencies with precision and confidence. With its focus on the application of the dicentric assay, the standard offers a scientifically robust framework for assessing radiation exposure levels, ultimately contributing to the safety and well-being of individuals affected by such events.

For laboratories seeking to enhance their capabilities in radiation protection and emergency response, the BS EN ISO 21243:2025 standard is an essential addition to their toolkit. By adhering to the principles and guidelines outlined in this standard, laboratories can ensure that they are prepared to deliver accurate and reliable dose assessments, even in the most challenging of circumstances.

DESCRIPTION

BS EN ISO 21243:2025


This standard BS EN ISO 21243:2025 Radiation protection. Performance criteria for laboratories performing initial cytogenetic dose assessment of mass casualties in radiological or nuclear emergencies. General principles and application to dicentric assay is classified in these ICS categories:
  • 13.280 Radiation protection
  • 27.120.20 Nuclear power plants. Safety
The purpose of this document is to give an overview of the minimum requirements for performing the dicentric assay with quality control measures using mitogen stimulated peripheral blood lymphocytes for initial assessment of individuals involved in a mass casualty scenario. The dicentric assay is the use of chromosome damage to quickly estimate approximate radiation doses received by individuals in order to supplement the early clinical categorization of casualties. This document focuses on the organizational and operational aspects of applying the dicentric assay in an initial assessment mode. The technical aspects of the dicentric assay can be found in ISO 19238. This document is applicable either to an experienced biological dosimetry laboratory working alone or to a network of collaborating laboratories (as defined in Clause 7).