This document addresses the following: a) the confidentiality of personal information for the customer and the laboratory; b) the laboratory safety requirements; c) the calibration sources and calibration dose ranges useful for establishing the reference doseresponse curves that contribute to the dose estimation from CBMN assay yields and the detection limit; d) the performance of blood collection, culturing, harvesting, and sample preparation for CBMN assay scoring; e) the scoring criteria; f) the conversion of micronucleus frequency in BNCs into an estimate of absorbed dose; g) the reporting of results; h) quality assurance and quality control; i) informative annexes containing sample instructions for customers, sample questionnaire, a microscope scoring data sheet, and a sample report.